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Before therapy is started, calcium levels should be checked and it is important for the patient to have adequate calcium and vitamin D supplementation during therapy. Please consult with your doctor about the long term use of Fosamax and the duration of treatment appropriate for you. For more specific information, consult with your doctor for guidance based on your health status and current medications, particularly before taking any action.

Kristen Dore, PharmD. A: Fosamax alendronate is a medication that is used to treat osteoporosis. Fosamax belongs to a group of medications called bisphosphonates that work by binding to cells in the bones and preventing them from breaking down. Fosamax does come in a generic form called alendronate and is available in several strengths including 5 mg, 10 mg, 35 mg, 40 mg and 70 mg.

It is made by many different manufacturers and your local pharmacy should have one of these in stock. Lori Poulin, PharmD. A: Fosamax alendronate belongs to a class of drugs called bisphosphonates that works by preventing the breakdown of bone. It can help slow bone loss and increase bone density or mass. Fosamax is used to treat or prevent osteoporosis and to treat a bone disease called Paget's disease. Common side effects of Fosamax include abdominal pain, constipation, diarrhea, gas, indigestion, bloating, vomiting, and headache.

More serious side effects are rare, but can occur. This includes a disorder called osteonecrosis of the jaw ONJ. Basically, ONJ is loss of bone or bone death in the jaw. Symptoms can include jaw pain, swelling, numbness, loose teeth, and infection pus draining from the area. ONJ is more likely to occur in people who have had recent dental surgery or tooth extractions.

Other conditions that may increase the risk of ONJ are cancer, poor oral hygiene, pre-existing dental diseases or gum diseases, anemias, ill-fitting dentures, and medications such as chemotherapy or corticosteroids. Prednisone is classified as a corticosteroid. Consult your doctor, dentist, or oral surgeon for proper evaluation of your jaw and to determine if you are experiencing ONJ. If ONJ is diagnosed, treatment by an oral surgeon is recommended.

This is not a complete list of risks and side effects that can occur with Fosamax.


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Sarah Lewis, PharmD. A: Fosamax alendronate is classified as a bisphosphonate. Fosamax is approved for the treatment and prevention of osteoporosis in women that are postmenopausal, treatment of osteoporosis in males, the treatment of Paget's disease, and the treatment of glucocorticoid induced osteoporosis in men and women. Fosamax, like any medication, has possible risks, warnings and side effects associated with its use. Under the warnings section of the prescribing information for Fosamax is a discussion regarding the possibility of gastrointestinal mucosa irritation that can occur with use of this medication.

Included is the possibility of esophageal ulcers. This is not all of the warnings associated with the medication. Fosamax has the following side effects reported by studied patients taking the medication: acid reflux, gastroesophageal reflux disease and gastric ulcer. These are not all of the possible side effects associated with Fosamax. Specific decisions regarding medication therapy is best made by your physician. Consult with your physician to determine if you should start taking Fosamax again.

According to a drug interaction report on your prescription medications: levothyroxine Synthroid, Levothroid, Levoxyl , protriptyline Vivactil , omeprazole Prilosec and Fosamax, there were no drug interactions detected. A: Fosamax alendronate belongs to the group of drugs called bisphosphonates. These drugs have been shown in scientific studies to increase bone mass and reduce fractures. Fosamax is approved for the treatment and prevention of postmenopausal osteoporosis. According to the prescribing information, most cases of osteonecrosis of the jaw have been in cancer patients undergoing dental procedures who received a bisphosphonate by injection.

However, some have occurred in patients with postmenopausal osteoporosis or other diagnoses who received the drug orally. The risk factors for osteonecrosis of the jaw include a diagnosis of cancer, use of other therapies including chemotherapy, radiation therapy, or corticosteroids, and other medical conditions, such as anemia, bleeding disorder, infection, or dental disease.

The length of time that side effects remain, after discontinuation of Fosamax, depends on several factors including he side effect itself and the length of time the drug stays in the body. With respect to the side effect, if you experienced irritation or ulceration of the esophagus or stomach, the lining of your gastrointestinal tract would need to heal before the side effect goes away. Bone and joint pain is reported to go away in most patients after stopping the drug. Fosamax remains in the body for a long time because it is stored in the bone.

However, the concentration of the drug in the blood after you stop taking it is approximately 25 percent of what it was when it is taken orally. If you are having side effects from your medication, please talk to your doctor. Do not stop or change your medication without first talking to your doctor. A: Fosmax alendronate is a prescription medication commonly used to treat osteoporosis and is also available as a combination product known as Fosamax plus D alendronate plus cholecalciferol.

Some of the most common side effects associated with Fosamax and Fosamax plus D are gastroesophageal reflux disease GERD , heartburn, nausea, vomiting, constipation, diarrhea, gas, abdominal pain, inflammation of the esophagus and esophageal ulcers. This is not a complete list of the side effects associated with Fosamax and Fosamax plus D. Fosamax or Fosamax plus D should be taken in the morning, with a full glass of water six to eight ounces , at least 30 minutes before food, drink, or other medication.

A: Fosamax alendronate is classified as a bisphosphonate derivative. Fosamax is approved for the treatment of osteoporosis in women that are postmenopausal, treatment of osteoporosis in males, the treatment of Paget's disease, and the treatment of glucocorticoid induced osteoporosis in men and women. Fosamax works in the body to inhibit bone resorption by affecting the actions of osteoclasts or the precursors to osteoclasts. Bone resorption is defined as the process in the body that occurs when osteoclasts break down bones.

This process releases the minerals, such as calcium, from the bones into the bloodstream. Therefore, Fosamax decreases bone resorption resulting in an increase in the bone mineral density. As a result of the way that Fosamax works, blood levels of calcium should be decreased instead of increased because, theoretically, less calcium is released from the bones into the blood.

In fact, hypocalcemia or low levels of calcium in the blood is one of the listed possible side effects associated with treatment with Fosamax. This is not the only associated side effect of the medication. Pseudogout is defined as a sudden swelling of a joint, or joints, that results from a form of arthritis. Pseudogout occurs when crystals of calcium pyrophosphate dihydrate CPPD develop around or in the joints.

The result is painful inflammation of the affected area. A review of medical literature discovered extremely rare reports of patients that were taking Fosamax developing pseudogout. It is stated, in a clinical study, that bisphosphonates are similiar in structure to pyrophosphate. However, the mechanism in which taking bisphosphonate medications could lead to deposits of CPPD crystals in and around the joints is unknown. The author of the study states that there are very few cases of this occuring considering the vast amount of patients that are treated with bisphosphonates.

It appears that additional studies need to be performed to fully understand this possible connection. Talk to your physician regarding the questions and concerns that you have regarding your medical conditions and your medications.

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The research revealed that the combination of Fosamax and HRT may increase protection from fractures. However, the long-term effects on fracture occurrence and fracture healing have not been studied. The concomitant use of Fosamax and hormonal treatments for breast cancer were not directly evaluated. For more information regarding the concomitant use of Fosamax and treatment of breast cancer, speak with your health care provider. Fosamax is categorized as a bisphosphonate which changes the cycle of bone formation and breakdown in your body.

Bisphosphonates slow bone loss and increase bone mass, which may prevent fractures. Fosamax is indicated for the treatment of steroid-induced osteoporosis in men and women, for the treatment and prevention of postmenopausal osteoporosis in women, and for the treatment of osteoporosis in men. Fosamax is also indicated for the treatment of Paget's disease, a disease of the bone. Fosamax is typically taken once weekly and should be taken first thing in the morning, at least 30 minutes before eating, drinking or taking any other medications.

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Fosamax should be taken on the same day each week. It is important to take each dose with approximately six to eight ounces of plain water. Do not crush, chew, break or suck on Fosamax tablets and swallow them whole. After administration of your weekly dose of Fosamax, do not lie down or recline, eat or drink anything but water, or take any other medications, including vitamins and supplements, for at least 30 minutes. The most commonly reported side effects associated with Fosamax include mild heartburn or stomach upset, constipation, diarrhea, gas, dizziness, weakness, headache, back or joint pain and swelling in the hands and feet.

If you experience any chest pain, difficult or painful swallowing, new or worsening heartburn, severe joint or muscle pain or jaw pain, numbness or swelling while taking Fosamax, contact your doctor immediately. A rare side effect associated with Fosamax treatment is jaw osteonecrosis. Risk factors for jaw osteonecrosis include cancer and various cancer therapies, anemia, infection and dental disease. According to the literature available, the effect on the jaw were mostly reported in patients receiving the drug through intravenous administration, although some reports were from patients receiving these medications orally.

If you are experiencing unusual or bothersome symptoms, or are concerned about the risk for jaw osteonecrosis, you may want to speak to you health care provider. Beth Isaac, PharmD. A: Increased potassium was not listed as a possible side effect of Fosamax alendronate , according to the prescribing information for the medication.

Fosamax is a bisphosphonate medication. Fosamax is approved for the treatment and prevention of postmenopausal osteoporosis in women, for the treatment of osteoporosis in men and for the treatment of steroid-induced osteoporosis in men and women. Fosamax is also approved for the treatment of Paget's disease, a disease of the bone.

Weekly Fosamax should be taken on the same day each week. The most commonly reported side effects possible with Fosamax include mild heartburn or stomach upset, constipation, diarrhea, gas, dizziness, weakness, headache, back or joint pain and swelling in hands and feet.

A rare side effect associated with Fosamax treatment is osteonecrosis of the jaw. According to the literature available, the effect on the jaw was mostly reported in patients receiving the drug through intravenous administration, although some reports were from patients receiving these medications orally.

A: According to the prescribing information for Fosamax alendronate , one of the side effects of bisphosphonates which may occur is called osteonecrosis of the jaw ONJ. Symptoms of ONJ may include pain, swelling, infection, poor healing, loosening of teeth, or numbness of the jaw. According to the National Osteoporosis Foundation, it is important for patients taking bisphosphonates to maintain good oral hygiene and have regular dental visits.

There was no mention of the development of osteonecrosis following a knee replacement in the prescribing information. Please consult with your health care provider in regards to your concerns and symptoms you may be experiencing. Drugs A-Z provides drug information from Everyday Health and our partners, as well as ratings from our members, all in one place. You can browse Drugs A-Z for a specific prescription or over-the-counter drug or look up drugs based on your specific condition. This information is for educational purposes only, and not meant to provide medical advice, treatment, or diagnosis.

Remember to always consult your physician or health care provider before starting, stopping, or altering a treatment or health care regimen. Every effort has been made to ensure that the information provided by on this page is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. The information on this page has been compiled for use by healthcare practitioners and consumers in the United States and therefore neither Everyday Health or its licensor warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise.

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The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. Neither Everyday Health nor its licensor assume any responsibility for any aspect of healthcare administered with the aid of the information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.

If you have any questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Everyday Health Drugs Bisphosphonates Fosamax. What Is Fosamax Alendronate? Fosamax Side Effects. Fosamax Interactions. Fosamax Dosage.

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